Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Halcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | PGR | P06401 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | AR | P10275 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halcinonide SCHEMBL5188866 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL10019829 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL7861670 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL13026159 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL4336 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL24015431 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL8467031 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL5489567 | 1.00 | NR3C1 (1.00) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL8529770 | 0.99 | NR3C1 (0.98) | NR3C1PGRCYP3A4ARUSP2 | |
| Halcinonide SCHEMBL2843940 | 0.99 | NR3C1 (0.98) | NR3C1PGRCYP3A4ARUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 24471 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137657-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137656-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-3820479-B1 | METHODS TO REDUCE COMPLICATIONS OF INTRA-ARTICULAR STEROID | TAIWAN LIPOSOME CO LTD (TW) | 2026-03-11 | — | — | EP | claimed |
| EP-3717017-B1 | COVALENT ANESTHETIC-POLYMER CONJUGATES FOR PROLONGED LOCAL ANESTHESIA | CHILDRENS MEDICAL CT CORP (US) | 2026-02-25 | — | — | EP | claimed |
| US-20260027255-A1 | Cross-Linked Telechelic Polymer Compositions, Methods of Preparation Thereof, and Methods of Using Same | BETTY YU SKIN TECH ADVISORS LLC (US) | 2026-01-29 | — | — | US | claimed |
| EP-0173478-A1 | Treatment of skin disorders | SCOTIA HOLDINGS PLC (GB) | 1986-03-05 | — | — | EP | claimed |
| EP-0068553-B1 | TOPICAL ANTIMICROBIAL ANTI-INFLAMMATORY COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1985-11-21 | — | — | EP | claimed |
| US-4427670-A | CONTAINING CORTICOSTEROID, PHOSPHATIDE, AND BUTYLHYDROXYANISOLE, OR BUTYLHYDROXYTOLUENE | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1984-01-24 | — | — | US | claimed |
| EP-0068553-A1 | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| US-4299828-A | Corticosteroid stick formulations | E. R. SQUIBB & SONS, INC. (US) | 1981-11-10 | — | — | US | claimed |
| EP-0020117-A2 | Corticosteroid formulations containing sebacate carrier | E.R. Squibb & Sons, Inc. (US) | 1980-12-10 | — | — | EP | claimed |
| US-4233295-A | TOPICAL TREATMENT OF DERMATITIS | E. R. SQUIBB & SONS, INC. (US) | 1980-11-11 | — | — | US | claimed |
| US-4230621-A | TRACERS, HYDROXYPHENYLGLUTARIC ACID DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1980-10-28 | — | — | US | claimed |
| US-4082881-A | STEROIDS, DERMATITIS | E. R. SQUIBB & SONS, INC. (US) | 1978-04-04 | — | — | US | claimed |