SCHEMBL43363

SCHEMBL43363

Fc1cc(Br)cc(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.44
ACP1 P24666 1/20 0.38
S1PR1 P21453 1/20 0.37
S1PR3 Q99500 1/20 0.37
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
RXRG P48443 1/20 0.36
TAS2R14 Q9NYV8 1/20 0.36
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
CES2 O00748 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA5A P35218 1/20 0.34
CA9 Q16790 1/20 0.34
P2RX4 Q99571 1/20 0.34
P2RX7 Q99572 1/20 0.34
S1PR2 O95136 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29365971 1.00 NOTUM (0.44) NOTUMACP1S1PR1S1PR3RXRA
Carbamic Acid SCHEMBL11786912 0.86 NOTUM (0.47) NOTUMACP1RXRARXRBRXRG
Tetrahydrofuran SCHEMBL8652793 0.84 NOTUM (0.36) NOTUMACP1S1PR1S1PR3TAS2R14
SCHEMBL131138 0.84 NOTUM (0.50) NOTUMACP1S1PR1S1PR3TAS2R14
SCHEMBL1082212 0.84 NOTUM (0.50) NOTUMACP1S1PR1S1PR3TAS2R14
SCHEMBL1445873 0.81 NOTUM (0.48) NOTUMACP1S1PR1S1PR3TAS2R14
SCHEMBL31749284 0.81 NOTUM (0.34) NOTUMCA1CA2CA5ACA9
SCHEMBL5779081 0.81 NOTUM (0.34) NOTUMCA1CA2CA5ACA9
SCHEMBL9693899 0.81 CES2 (0.42) RXRARXRBRXRGHDAC3HDAC1
SCHEMBL4461544 0.81 CES2 (0.48) RXRARXRBRXRGHDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 509 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114957312-A Aryl silicon compound of conjugated olefin and preparation method and application thereof 南京工业大学 2022-08-30 CN claimed
EP-3543319-A1 METHOD OF MARKING HYDROCARBON LIQUIDS Johnson Matthey Public Limited Company (GB) 2019-09-25 EP claimed
US-20140120626-A1 METHOD OF MARKING HYDROCARBON LIQUIDS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2014-05-01 US claimed
EP-2707465-A1 METHOD OF MARKING HYDROCARBON LIQUIDS Johnson Matthey Public Limited Company (GB) 2014-03-19 EP claimed
CN-102174019-B Method for synthesizing organic compounds NOVARTIS AG 2013-02-13 CN claimed
WO-2012153132-A1 METHOD OF MARKING HYDROCARBON LIQUIDS JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2012-11-15 WO claimed
EP-1896426-B1 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS NOVARTIS AG (CH) 2012-01-11 EP claimed
CN-102174019-A method for synthesizing organic compounds NOVARTIS AG 2011-09-07 CN claimed
US-20100280257-A1 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS ABEL STEPHAN 2010-11-04 US claimed
US-20080200692-A1 Process For the Synthesis of Organic Compounds NOVARTIS AG (CH) 2008-08-21 US claimed
CN-101189212-A Method for synthesizing organic compounds NOVARTIS AG (CH) 2008-05-28 CN claimed
EP-1896426-A2 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS Novartis AG (CH) 2008-03-12 EP claimed
WO-2006135640-A2 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS NOVARTIS AG (CH) 2006-12-21 WO claimed
US-12552801-B2 Indazole derivatives HOFFMANN-LA ROCHE INC. (US) 2026-02-17 US disclosed
WO-2025264844-A1 HETEROCYCLIC GPR52 MODULATORS AND METHODS OF USE THEREOF LIEBER INSTITUTE, INC. (US) 2025-12-26 WO disclosed
WO-2025264837-A1 NAPHTHYRIDINE GPR52 MODULATORS AND METHODS OF USE THEREOF LIEBER INSTITUTE, INC. (US) 2025-12-26 WO disclosed
US-5098930-A Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-24 US disclosed
EP-0409413-A2 Diaryl ether heterocycles IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-01-23 EP disclosed
EP-0385662-A2 Heterocycles with inhibitory activity of 5-lipoxygenase ZENECA LIMITED (GB) 1990-09-05 EP disclosed
EP-0375404-A2 Heterocyclic derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-06-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080200692-A1 Process For the Synthesis of Organic Compounds ODC1, AZI2, NISCH NOTUM 2412/4885ACP1 3217/4885S1PR1 4380/4885
US-20100280257-A1 PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS ODC1, AZI2, NISCH NOTUM 2412/4885ACP1 3217/4885S1PR1 4380/4885
US-12552801-B2 Indazole derivatives EGFR, ABL1, ERBB3 NOTUM 2985/4885ACP1 1473/4885S1PR1 2469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.