SCHEMBL4338064

SCHEMBL4338064

COCCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)Nc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.55
TLR8 Q9NR97 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29714531 1.00 TLR7 (0.55) TLR7TLR8
SCHEMBL5354266 0.92 TLR7 (0.63) TLR7
SCHEMBL5800432 0.91 TLR7 (0.60) TLR7TLR8
SCHEMBL6098681 0.91 TLR7 (0.56) TLR7TLR8
SCHEMBL13613796 0.91 TLR7 (0.61) TLR7TLR8
SCHEMBL5353603 0.91 TLR7 (0.59) TLR7TLR8
SCHEMBL30345323 0.91 TLR8 (0.56) TLR7TLR8
SCHEMBL5057099 0.91 TLR8 (0.56) TLR7TLR8
SCHEMBL6813136 0.90 TLR7 (0.56) TLR7TLR8
SCHEMBL6098376 0.89 TLR7 (0.62) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230390410-A1 COMPOUNDS AND COMPOSITIONS FOR IMMUNOTHERAPY BIRDIE BIOPHARMACEUTICALS INC (KY) 2023-12-07 US claimed
US-11633494-B2 Compounds and compositions for immunotherapy BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2023-04-25 US claimed
US-11633495-B2 Compounds and compositions for immunotherapy BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2023-04-25 US claimed
EP-4148069-A1 ANTI-PD-L1 CONJUGATES FOR TREATING TUMORS Birdie Biopharmaceuticals Inc. (KY) 2023-03-15 EP claimed
CN-115554406-A anti-CD 20 combinations for the treatment of tumors 博笛生物科技有限公司 2023-01-03 CN claimed
CN-115350279-A anti-HER 2 combinations for the treatment of tumors 博笛生物科技有限公司 2022-11-18 CN claimed
CN-115337402-A Combination therapeutic compositions and combination therapeutic methods for treating cancer 博笛生物科技有限公司 2022-11-15 CN claimed
CN-115252792-A anti-EGFR combinations for the treatment of tumors 博笛生物科技有限公司 2022-11-01 CN claimed
CN-114716555-A Compounds and compositions for targeting EGFR expressing tumors 博笛生物科技有限公司 2022-07-08 CN claimed
CN-114671954-A Compounds and compositions targeting HER2 positive tumors 博笛生物科技有限公司 2022-06-28 CN claimed
US-20160324983-A1 Compounds and Compositions for Immunotherapy SHANGHAI BIRDIE BIOTECH, INC. (CN) 2016-11-10 US claimed
US-7612083-B2 Urea substituted imidazoquinoline ethers COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-11-03 US claimed
US-7049439-B2 Immunomodulators for inducing cytokine biosynthesis; viricides; antitumor agents 3M INNOVATIVE PROPERTIES CO. (US) 2006-05-23 US claimed
EP-1343784-B1 UREA SUBSTITUTED IMIDAZOQUINOLINE ETHERS and pharmaceutical compositions comprising the same. 3M INNOVATIVE PROPERTIES CO (US) 2006-03-08 EP claimed
US-20050234088-A1 Urea substituted imidazoquinoline ethers 3M INNOVATIVE PROPERTIES COMPANY 2005-10-20 US claimed
US-20040077678-A1 Urea substituted imidazoquinoline ethers 3M INNOVATIVE PROPERTIES COMPANY 2004-04-22 US claimed
US-20040072859-A1 Urea substituted imidazoquinoline ethers 3M INNOVATIVE PROPERTIES COMPANY 2004-04-15 US claimed
US-6656938-B2 Inducing cytokine biosynthesis in animals, for the treatment of diseases, including viral and neoplastic diseases 3M INNOVATIVE PROPERTIES COMPANY 2003-12-02 US claimed
US-20030158192-A1 Urea substituted imidazoquinoline ethers 3M INNOVATIVE PROPERTIES COMPANY 2003-08-21 US claimed
US-20030130518-A1 Urea substituted imidazoquinoline ethers COLEY PHARMACEUTICAL GROUP, INC. 2003-07-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11633494-B2 Compounds and compositions for immunotherapy CD47, CD274, TP53 TLR7 147/4885TLR8 313/4885
US-20040072859-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 84/4885TLR8 273/4885
US-11633495-B2 Compounds and compositions for immunotherapy CD47, CD274, TP53 TLR7 147/4885TLR8 313/4885
US-20030158192-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 84/4885TLR8 273/4885
US-20160324983-A1 Compounds and Compositions for Immunotherapy CD47, TP53, CD74 TLR7 198/4885TLR8 159/4885
US-20050234088-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 74/4885TLR8 257/4885
US-20030130518-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 84/4885TLR8 273/4885
US-20040077678-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 84/4885TLR8 273/4885
US-20230390410-A1 COMPOUNDS AND COMPOSITIONS FOR IMMUNOTHERAPY CD47, CD274, TP53 TLR7 147/4885TLR8 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.