Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 2/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055228 | 1.00 | P2RY6 (0.43) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL1054333 | 0.94 | P2RY6 (0.44) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL1052213 | 0.92 | P2RY6 (0.42) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL1054670 | 0.87 | P2RY6 (0.42) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL6928957 | 0.84 | P2RY6 (0.55) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL12636350 | 0.84 | P2RY6 (0.48) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL4338085 | 0.82 | P2RY6 (0.42) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL31390238 | 0.82 | P2RY6 (0.50) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL7268016 | 0.80 | P2RY6 (0.52) | P2RY6P2RY14NT5EABL1RIN1 | |
| SCHEMBL8038972 | 0.80 | ABL1 (0.43) | P2RY6P2RY14NT5EABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677822-A4 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1677822-A2 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005027962-A1 | 4’-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |