Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22614909 | 0.73 | KDM4E (0.35) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL10670682 | 0.72 | KDM4E (0.67) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL4990063 | 0.70 | KDM4E (1.00) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL29929816 | 0.70 | KDM4E (1.00) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL2874734 | 0.70 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL22612633 | 0.70 | ALDH1A1 (0.51) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL2873139 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL1531483 | 0.68 | CDK2 (0.57) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL2865775 | 0.67 | HSP90AA1 (0.50) | KDM4EALDH1A1POLBHTTMAPT | |
| SCHEMBL4516423 | 0.67 | CDK2 (0.60) | KDM4EALDH1A1POLBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595987-A1 | NEW AMINOPYRAZOLOQUINAZOLINES | Boehringer Ingelheim International GmbH (DE) | 2013-05-29 | — | — | EP | claimed |
| WO-2012010704-A1 | NEW AMINOPYRAZOLOQUINAZOLINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-26 | — | — | WO | claimed |
| WO-2020223469-A1 | N-(1-(METHYLSULFONYL)PIPERIDIN-4-YL)-4,5-DI HYDRO-1H-IMIDAZO[4,5-H]QUINAZOLIN-8-AMINE DERIVATIVES AND RELATED COMPOUNDS AS CYCLIN-DEPENDENT KINASE 2 (CDK2) INHIBITORS FOR TREATING CANCER | INCYTE CORPORATION (US) | 2020-11-05 | — | — | WO | disclosed |
| EP-2595987-A1 | NEW AMINOPYRAZOLOQUINAZOLINES | Boehringer Ingelheim International GmbH (DE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010704-A1 | NEW AMINOPYRAZOLOQUINAZOLINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-26 | — | — | WO | disclosed |