Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.48 |
| ▸ | WNT3A | P56704 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22396834 | 0.90 | MRGPRX4 (0.49) | MRGPRX4CTNNB1WNT3AKMT2AMEN1 | |
| SCHEMBL5280215 | 0.87 | MRGPRX4 (0.44) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 | |
| SCHEMBL5283330 | 0.86 | MRGPRX4 (0.49) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 | |
| SCHEMBL13222490 | 0.82 | MRGPRX4 (0.46) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 | |
| SCHEMBL14941881 | 0.80 | KMT2A (0.47) | MRGPRX4CTNNB1WNT3ASMYD3KMT2A | |
| SCHEMBL19555277 | 0.79 | MRGPRX4 (0.59) | MRGPRX4CTNNB1WNT3AALDH1A1LMNA | |
| SCHEMBL22396831 | 0.77 | MRGPRX4 (0.47) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 | |
| SCHEMBL7030084 | 0.76 | LMNA (0.42) | KMT2AMEN1USP2ALDH1A1LMNA | |
| SCHEMBL5278237 | 0.75 | MRGPRX4 (0.44) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 | |
| SCHEMBL17973954 | 0.75 | MRGPRX4 (0.41) | MRGPRX4CTNNB1WNT3AHDAC4SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727799-B1 | NOVEL ALKYL-CONTAINING 5-ACYLINDOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PRODUCTS | BOEHRINGER INGELHEIM INT (DE) | 2009-01-07 | — | — | EP | disclosed |
| EP-1727812-B1 | NOVEL CYCLOALKYL-CONTAINING 5-ACYLINDOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL PRODUCTS | BOEHRINGER INGELHEIM INT (DE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1727798-B1 | NOVEL ARYL-CONTAINING 5-ACYLINDOLINONES, THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2008-10-29 | — | — | EP | disclosed |
| EP-1595876-B1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | SALTIGO GMBH (DE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006072351-A1 | HETEROARYL-SUBSTITUITED PYRAZOLINES AS PAR-1 ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2006-07-13 | — | — | WO | disclosed |
| EP-1595876-A1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| EP-1595876-A1 | Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2002012236-A1 | SUBSTITUTED TRIAZOLOPYRID(AZ)INES AS PLANT TREATMENT AGENTS (HERBICIDES) | BAYER CROPSCIENCE AG (DE) | 2002-02-14 | — | — | WO | disclosed |