Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461844 | 0.82 | MAPT (0.70) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL14880163 | 0.82 | MAPT (0.69) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL9906903 | 0.82 | MAPT (0.69) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL13753341 | 0.81 | RAB9A (0.70) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL8340106 | 0.80 | RAB9A (0.73) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL6361574 | 0.78 | RAB9A (0.66) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL13753400 | 0.77 | MAPT (0.62) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL5799680 | 0.77 | MAPT (0.62) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL388833 | 0.77 | MAPT (0.62) | MAPTKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL9375468 | 0.76 | MAPT (0.61) | MAPTKDM4ERAB9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009094205-A2 | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2009-07-30 | — | — | WO | disclosed |