SCHEMBL4338427

SCHEMBL4338427

CCOc1cc(C(Nc2ccc(C(=N)NC(=O)OCc3ccccc3)cc2)C(=O)OC)ccc1OC(C)C

nearest known ligand 0.59

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F7 P08709 20/20 0.59
F3 P13726 12/20 0.59
F10 P00742 11/20 0.59
F2 P00734 10/20 0.59
PRSS1 P07477 7/20 0.59
PRSS2 P07478 3/20 0.59
PRSS3 P35030 3/20 0.59
F11 P03951 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4335707 0.95 F7 (0.66) F7F3F10F2PRSS1
SCHEMBL4340755 0.95 F7 (0.66) F7F3F10F2PRSS1
SCHEMBL2542910 0.86 F7 (0.44) F7F3F10F2PRSS1
SCHEMBL13613719 0.86 F7 (0.56) F7F3F10F2PRSS1
SCHEMBL2544588 0.84 F7 (0.47) F7F3F10F2PRSS1
SCHEMBL3463923 0.83 F7 (0.69) F7F3F10F2PRSS1
SCHEMBL5883152 0.79 F7 (0.59) F7F3F10F2PRSS1
SCHEMBL3853926 0.77 F7 (0.56) F7F3F10F2PRSS1
SCHEMBL13162824 0.77 F7 (0.69) F7F3F10F2PRSS1
SCHEMBL5882886 0.77 F7 (0.81) F7F3F10F2PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7622585-B2 Phenylglycinamide derivatives useful as anticoagulants BRISTOL-MYERS SQUIBB COMPANY (US) 2009-11-24 US disclosed
US-7622585-B2 Phenylglycinamide derivatives useful as anticoagulants BRISTOL-MYERS SQUIBB COMPANY (US) 2009-11-24 US disclosed
EP-1856096-A2 PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS Bristol-Myers Squibb Company (US) 2007-11-21 EP disclosed
US-20060166997-A1 Phenylglycinamide derivatives useful as anticoagulants BRISTOL-MYERS SQUIBB COMPANY 2006-07-27 US disclosed
WO-2006076246-A2 PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-07-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060166997-A1 Phenylglycinamide derivatives useful as anticoagulants TFPI, SERPINC1, SERPINE1 F7 35/4885F3 20/4885F10 43/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.