Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.67 |
| ▸ | PDE5A | O76074 | 6/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2709876 | 0.89 | MIF (0.74) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL655570 | 0.89 | MIF (0.78) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL7508100 | 0.88 | MIF (0.72) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL7509505 | 0.85 | MIF (0.76) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL22947697 | 0.85 | MIF (1.00) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL3185498 | 0.85 | MIF (0.76) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL3192726 | 0.85 | MIF (0.76) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL3197152 | 0.81 | PDE4B (0.76) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL653503 | 0.81 | PDE4B (0.76) | MIFPDE4BPDE5APDE3ATSHR | |
| SCHEMBL30319231 | 0.81 | PDE4B (0.75) | MIFPDE4BPDE5APDE3ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026804-A1 | IBUDILAST FOR INHIBITING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) ACTIVITY | Avigen, Inc. (US) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007142924-A1 | IBUDILAST FOR INHIBITING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) ACTIVITY | AVIGEN, INC. (US) | 2007-12-13 | — | — | WO | disclosed |
| EP-0368343-A2 | Ameliorating composition for dysmnesia | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1990-05-16 | — | — | EP | disclosed |