Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332632 | 0.91 | PTPN11 (0.41) | PTGER1KDM4EKMOKDM4CCSNK1D | |
| SCHEMBL4334488 | 0.83 | PTGER1 (0.37) | PTGER1KDM4ECSNK1DCSNK1EGPR35 | |
| SCHEMBL4341004 | 0.82 | PTGER1 (0.36) | PTGER1KMOKDM4CCSNK1DCSNK1E | |
| SCHEMBL4336324 | 0.76 | PTGER1 (0.38) | PTGER1KDM4ECSNK1DCSNK1EDCLRE1B | |
| SCHEMBL31633015 | 0.74 | SCN9A (0.48) | PTGER1KDM4EKMOKDM4CCSNK1D | |
| SCHEMBL4334606 | 0.74 | PTPN11 (0.41) | PTGER1KDM4ECSNK1DCSNK1ETACR3 | |
| SCHEMBL4336462 | 0.74 | CSNK1D (0.38) | PTGER1KDM4ECSNK1DDCLRE1BGPR35 | |
| SCHEMBL4348125 | 0.72 | PTGER1 (0.41) | PTGER1KDM4EKMOCSNK1DCSNK1E | |
| SCHEMBL4340976 | 0.72 | MAPT (0.38) | PTGER1KDM4ECSNK1DCSNK1ETACR3 | |
| SCHEMBL2870394 | 0.72 | PTGER1 (0.43) | PTGER1KDM4EKMOCSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | PTGER1 3143/4885KDM4E 2531/4885KMO 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.