Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336462 | 0.82 | CSNK1D (0.38) | PTGER1KDM4EGPR35PTGFRCSNK1D | |
| SCHEMBL4340947 | 0.82 | PTGER1 (0.36) | PTGER1CSNK1DCSNK1EDCLRE1BNOTUM | |
| SCHEMBL4348125 | 0.81 | PTGER1 (0.41) | PTGER1KDM4EGPR35PTGFRCSNK1D | |
| SCHEMBL4333982 | 0.81 | PTGER1 (0.36) | PTGER1PTGFRCSNK1DCSNK1ECSNK2A2 | |
| SCHEMBL4335000 | 0.80 | PTGER1 (0.36) | PTGER1RORCPTGFRCSNK1DCSNK1E | |
| SCHEMBL4328987 | 0.79 | CTSA (0.41) | PTGER1 | |
| SCHEMBL4343207 | 0.76 | PTGER1 (0.38) | PTGER1KDM4EGPR35PTGFRCSNK1D | |
| SCHEMBL4342241 | 0.75 | CSNK1E (0.34) | PTGER1KDM4EGPR35RORCPTGFR | |
| SCHEMBL4332632 | 0.75 | PTPN11 (0.41) | PTGER1KDM4EGPR35CSNK1DCSNK1E | |
| SCHEMBL4332233 | 0.75 | RELA (0.37) | PTGER1CSNK1ECSNK2A2CSNK2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541376-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20050282880-A1 | Novel 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282880-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | PTGER1 3143/4885KDM4E 2531/4885GPR35 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.