Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 7/20 | 0.39 |
| ▸ | AKT2 | P31751 | 5/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343581 | 1.00 | GSK3B (0.44) | GSK3BPIM1CDC7ROCK2PRKACA | |
| Hydrochloric Acid SCHEMBL4343338 | 0.91 | GSK3B (0.44) | GSK3BPIM1KMT2AHDAC1AKT1 | |
| Hydrochloric Acid SCHEMBL4343333 | 0.91 | GSK3B (0.44) | GSK3BPIM1KMT2AHDAC1AKT1 | |
| SCHEMBL4348275 | 0.89 | GSK3B (0.52) | GSK3BKMT2AHDAC1AKT1AKT2 | |
| SCHEMBL4348278 | 0.89 | GSK3B (0.52) | GSK3BKMT2AHDAC1AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL4349297 | 0.89 | AKT1 (0.48) | GSK3BPIM1CDC7ROCK2PRKACA | |
| Hydrochloric Acid SCHEMBL4349299 | 0.89 | AKT1 (0.48) | GSK3BPIM1CDC7ROCK2PRKACA | |
| Hydrochloric Acid SCHEMBL4348323 | 0.89 | GSK3B (0.51) | GSK3BKMT2AHDAC1AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL4348331 | 0.89 | GSK3B (0.51) | GSK3BKMT2AHDAC1AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL4348650 | 0.87 | AKT1 (0.50) | GSK3BPIM1CDC7ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |