Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 6/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473990 | 0.86 | TACR1 (0.45) | TACR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL4030849 | 0.85 | TACR1 (0.47) | TACR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL4021339 | 0.75 | PDK1 (0.42) | TACR1PDK1PDK2PDK3PDK4 | |
| SCHEMBL4023287 | 0.73 | TACR1 (0.44) | TACR1 | |
| SCHEMBL4022849 | 0.73 | TACR1 (0.44) | TACR1 | |
| SCHEMBL4022125 | 0.73 | TACR1 (0.44) | TACR1 | |
| SCHEMBL4023028 | 0.71 | TACR1 (0.63) | TACR1 | |
| SCHEMBL4023186 | 0.71 | TACR1 (0.45) | TACR1 | |
| SCHEMBL4030424 | 0.71 | TMEM97 (0.46) | NPC1PTGDR2 | |
| SCHEMBL4030300 | 0.70 | TACR1 (0.53) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460066-B1 | Piperazine compounds as Tachykinins inhibitors | GLAXO GROUP LTD (GB) | 2009-07-01 | — | — | EP | disclosed |