Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15071827 | 0.82 | MEN1 (0.47) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL2935415 | 0.79 | MEN1 (0.48) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL13477401 | 0.79 | KMT2A (0.47) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL4347031 | 0.79 | MEN1 (0.47) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL13140630 | 0.76 | MEN1 (0.43) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL2219482 | 0.75 | ALDH1A1 (0.58) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL2937635 | 0.75 | ALDH1A1 (0.46) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL13140934 | 0.70 | NAMPT (0.42) | POLBKDM4E | |
| SCHEMBL15493696 | 0.70 | KDM4E (0.41) | ALDH1A1HTTMEN1KMT2ACYP1A2 | |
| SCHEMBL17067450 | 0.70 | ALDH1A1 (0.41) | ALDH1A1HTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242974-B2 | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140073797-A1 | PROCESSES FOR THE PREPARATION OF 2-FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-8552162-B2 | Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| WO-2009137787-A1 | PROCESSES FOR THE PREPARATION OF 2-FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-20090281293-A1 | PROCESSES FOR THE PREPARATION OF 2 FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES | ENANTA PHARMACEUTICALS, INC. | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073797-A1 | PROCESSES FOR THE PREPARATION OF 2-FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES | CYP2F1, CYP2B6, CYP4F11 | ALDH1A1 4501/4885HTT 3074/4885MEN1 3620/4885 |
| US-20090281293-A1 | PROCESSES FOR THE PREPARATION OF 2 FLUORO 6-11 BICYCLIC ERYTHROMYCIN DERIVATIVES | CYP2F1, CYP2B6, CYP4F11 | ALDH1A1 4493/4885HTT 3227/4885MEN1 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.