Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.73 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | BLK | P51451 | 1/20 | 0.62 |
| ▸ | BMX | P51813 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4194286 | 0.98 | EGFR (0.74) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL4187737 | 0.90 | EGFR (0.74) | EGFRERBB2 | |
| SCHEMBL4191758 | 0.88 | EGFR (0.75) | EGFRERBB2 | |
| SCHEMBL7214980 | 0.86 | EGFR (0.63) | EGFRERBB2ERBB4 | |
| SCHEMBL4187489 | 0.85 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL4187480 | 0.84 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL2987362 | 0.84 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2987364 | 0.84 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL7219991 | 0.83 | EGFR (0.64) | EGFRERBB2ERBB4 | |
| SCHEMBL4194478 | 0.83 | EGFR (0.73) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |