Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219991 | 0.98 | EGFR (0.64) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL4180544 | 0.91 | EGFR (0.71) | EGFRERBB2ERBB4 | |
| SCHEMBL4194333 | 0.88 | EGFR (0.72) | EGFRERBB2ERBB4 | |
| SCHEMBL4346100 | 0.86 | EGFR (0.73) | EGFRERBB2ERBB4 | |
| SCHEMBL4201064 | 0.85 | EGFR (0.72) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL4187414 | 0.84 | EGFR (0.68) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL4194286 | 0.83 | EGFR (0.74) | EGFRERBB2ERBB4 | |
| SCHEMBL4185100 | 0.83 | EGFR (0.68) | EGFRERBB2ERBB4AURKB | |
| SCHEMBL7220082 | 0.79 | EGFR (0.78) | EGFRERBB2ERBB4 | |
| SCHEMBL4185060 | 0.79 | EGFR (0.49) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |