Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346657 | 1.00 | GPR88 (0.43) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4349068 | 0.92 | DYRK1A (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4355957 | 0.92 | DYRK1A (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4355953 | 0.92 | DYRK1A (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4349063 | 0.92 | DYRK1A (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4347649 | 0.89 | GSK3B (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4347658 | 0.89 | GSK3B (0.44) | GPR88ROCK2ROCK1GSK3BDYRK1A | |
| SCHEMBL4352493 | 0.86 | GSK3B (0.45) | ROCK1GSK3BFLT3JAK3KMT2A | |
| SCHEMBL4352488 | 0.86 | GSK3B (0.45) | ROCK1GSK3BFLT3JAK3KMT2A | |
| SCHEMBL4667866 | 0.85 | GPR88 (0.42) | GPR88ROCK2ROCK1RPS6KB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |