Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344552 | 0.90 | NAMPT (0.57) | EPHX2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL4348632 | 0.86 | CSNK1D (0.53) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6519124 | 0.83 | MAPT (0.47) | MAPTRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL4561504 | 0.80 | MAPT (0.54) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL4352804 | 0.80 | MAPT (0.56) | MAPTRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4351106 | 0.80 | CNR1 (0.68) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6251830 | 0.79 | NAMPT (0.37) | EPHX2MAPTRAB9ANPC1MEN1 | |
| SCHEMBL4341723 | 0.78 | MAPT (0.49) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL4354538 | 0.78 | SMN1; SMN2 (0.52) | MAPTRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4355895 | 0.77 | RAB9A (0.58) | EPHX2MAPTRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |