SCHEMBL4347292

SCHEMBL4347292

O=C(O)[C@H]1CN(C(=O)O)CC[C@H]1c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.46
HRH3 Q9Y5N1 2/20 0.44
RAB9A P51151 3/20 0.44
NPC1 O15118 2/20 0.44
ATM Q13315 1/20 0.44
TLR2 O60603 1/20 0.43
TLR1 Q15399 1/20 0.43
NOTUM Q6P988 1/20 0.42
MAPT P10636 2/20 0.40
CACNA1B Q00975 2/20 0.39
HSD11B1 P28845 2/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
SLC9A1 P19634 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2820611 0.86 SLC6A2 (0.50) SIGMAR1HRH3RAB9ANPC1TLR2
SCHEMBL2817414 0.86 SLC6A2 (0.50) SIGMAR1HRH3RAB9ANPC1TLR2
SCHEMBL2818059 0.86 SLC6A2 (0.50) SIGMAR1HRH3RAB9ANPC1TLR2
SCHEMBL23924235 0.86 TLR2 (0.46) SIGMAR1HRH3RAB9ANPC1ATM
SCHEMBL2817342 0.86 SLC6A2 (0.50) SIGMAR1HRH3RAB9ANPC1TLR2
SCHEMBL23924236 0.86 TLR2 (0.46) SIGMAR1HRH3RAB9ANPC1ATM
SCHEMBL18586185 0.86 SLC6A2 (0.50) SIGMAR1HRH3RAB9ANPC1TLR2
SCHEMBL14920513 0.85 SLC6A2 (0.57)
SCHEMBL6041432 0.84 RAB9A (0.45) SIGMAR1HRH3RAB9ANPC1ATM
SCHEMBL7255955 0.82 SLC6A2 (0.57)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029541-A1 PROCESS FOR PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOXYLIC ACIDS F. Hoffmann-Roche AG (CH) 2009-03-04 EP disclosed
EP-2004605-A1 PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS F. Hoffmann-Roche AG (CH) 2008-12-24 EP disclosed
WO-2007113155-A1 PROCESS FOR PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC Β-ARYL OR HETEROARYL CARBOXYLIC ACIDS F. HOFFMANN-LA ROCHE AG (CH) 2007-10-11 WO disclosed
WO-2007113153-A1 PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2007-10-11 WO disclosed