Guanine

Guanine

SCHEMBL4348108

Cc1c[nH]c(=O)[nH]c1=O.Nc1nc2nc[nH]c2c(=O)[nH]1.Nc1ncnc2nc[nH]c12

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.58
XDH P47989 5/20 0.49
PI4KA P42356 3/20 0.49
PI4K2B Q8TCG2 3/20 0.49
PI4K2A Q9BTU6 3/20 0.49
PI4KB Q9UBF8 3/20 0.49
LMNA P02545 1/20 0.49
DRD3 P35462 1/20 0.49
LRRK2 Q5S007 1/20 0.49
ATAD2 Q6PL18 1/20 0.42
GDA Q9Y2T3 1/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
HPGD P15428 1/20 0.39
KMT2A Q03164 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL6130674 1.00 PNP (0.58) PNPXDHPI4KAPI4K2BPI4K2A
Guanine SCHEMBL17542296 0.92 PNP (0.49) PNPXDHPI4KAPI4K2BPI4K2A
Adenine SCHEMBL8860590 0.91 PI4KA (0.59) PNPXDHPI4KAPI4K2BPI4K2A
Adenine SCHEMBL4633068 0.91 PI4KA (0.59) PNPXDHPI4KAPI4K2BPI4K2A
Adenine SCHEMBL906215 0.91 PI4KA (0.59) PNPXDHPI4KAPI4K2BPI4K2A
Guanine SCHEMBL1375444 0.91 PNP (0.70) PNPXDHATAD2GDAALDH1A1
Guanine SCHEMBL6515057 0.91 PNP (0.70) PNPXDHATAD2GDAALDH1A1
Guanine SCHEMBL2128709 0.91 PNP (0.70) PNPXDHATAD2GDAALDH1A1
Guanine SCHEMBL29171220 0.91 PNP (0.70) PNPXDHATAD2GDAALDH1A1
Guanine SCHEMBL5097009 0.91 PNP (0.47) PNPXDHPI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9796996-B2 Means and methods for distinguishing FECV and FIPV UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2017-10-24 US disclosed
US-20160326582-A1 METHOD AND KIT FOR TARGET MOLECULE CHARACTERIZATION Fry Laboratories, L.L.C. 2016-11-10 US disclosed
WO-2016011086-A2 METHOD AND KIT FOR PROTOZOA CHARACTERIZATION Fry Laboratories, LLC (US) 2016-01-21 WO disclosed
US-20150344975-A1 COMPOSITIONS AND METHODS FOR DETECTING, EXTRACTING, VISUALIZING, AND IDENTIFYING PROTOMYXZOA RHUEMATIC Fry Laboratories, L.L.C. 2015-12-03 US disclosed
EP-2526209-B1 MEANS AND METHODS FOR DISTINGUISHING FECV AND FIPV UNIV UTRECHT HOLDING BV (NL) 2015-03-18 EP disclosed
US-20140349293-A1 METHOD AND KIT FOR PROTOZOA CHARACTERIZATION Fry Laboratories, L.L.C. 2014-11-27 US disclosed
US-8778843-B1 Semi-pan-protozoal by quantitative PCR Fry Laboratories, L.L.C. (US) 2014-07-15 US disclosed
US-20130071833-A1 MEANS AND METHODS FOR DISTINGUISHING FECV AND FIPV UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2013-03-21 US disclosed
EP-1217072-B1 Method for the preparation of an expression vector for the production of therapeutic proteins in transgenic animals BIOPHARM VYZKUMNY USTAV BIOFAR (CZ) 2009-07-22 EP disclosed
US-7319026-B2 Amino acid-producing bacteria and a process for preparing L-amino acids DEGUSSA AG (DE) 2008-01-15 US disclosed
US-4571421-A CODING FOR SOMATOSTATIN GENENTECH, INC. (US) 1986-02-18 US disclosed
US-4563424-A GENETIC ENGINEERING GENENTECH, INC. (US) 1986-01-07 US disclosed
EP-0166410-A2 Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1986-01-02 EP disclosed
US-4431739-A CLONING VEHICLES FOR HETEROLOGOUS DNA CODING OF SOMATOSTATIN, HAPTENS, INSULIN AND OTHER POLYPETIDES GENENTECH, INC. (US) 1984-02-14 US disclosed
US-4425437-A POLYPEPTIDES, PLASMIDS, CLONING GENENTECH, INC. (US) 1984-01-10 US disclosed
US-4366246-A Method for microbial polypeptide expression GENENTECH, INC. (US) 1982-12-28 US disclosed
US-4356270-A Recombinant DNA cloning vehicle GENENTECH, INC. (US) 1982-10-26 US disclosed
EP-0001930-A2 Method for polypeptide production involving expression of a heterologous gene, recombinant microbial cloning vehicle containing said gene and bacterial culture transformed by said cloning vehicle GENENTECH, INC. (US) 1979-05-16 EP disclosed
EP-0001929-A2 Plasmid for transforming bacterial host to render it capable of polypeptide expression GENENTECH, INC. (US) 1979-05-16 EP disclosed
EP-0001931-A2 Synthetic DNA, process for preparing it and recombinant microbial cloning vehicle containing such DNA GENENTECH, INC. (US) 1979-05-16 EP disclosed