Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886933 | 0.76 | BRD4 (0.39) | BRD4 | |
| SCHEMBL4348169 | 0.75 | KDM4E (0.42) | DHFRDYRK1ADYRK1BMERTKCDK1 | |
| SCHEMBL1053839 | 0.74 | BRD4 (0.36) | MEN1KMT2ALMNAHSD17B10BRD4 | |
| SCHEMBL1880673 | 0.74 | BRD4 (0.36) | BRD4 | |
| SCHEMBL25378764 | 0.61 | KDM4E (0.47) | DHFRKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL13157379 | 0.61 | MEN1 (0.46) | MERTKCDK1KDM4EALDH1A1MEN1 | |
| SCHEMBL651364 | 0.61 | BRD4 (0.38) | BRD4 | |
| SCHEMBL22725607 | 0.60 | ALDH1A1 (0.48) | DHFRCDK1KDM4EALDH1A1MEN1 | |
| SCHEMBL12593916 | 0.59 | — | — | |
| SCHEMBL14336338 | 0.58 | ALDH1A1 (0.54) | DHFRKDM4EALDH1A1MEN1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |