Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434072 | 0.82 | TSHR (0.32) | TSHRHSD17B10KEAP1NFE2L2KMT2A | |
| SCHEMBL18294829 | 0.82 | TSHR (0.32) | TSHRHSD17B10KEAP1NFE2L2KMT2A | |
| SCHEMBL434902 | 0.77 | NPC1 (0.33) | TSHRHSD17B10NPC1RAB9ATDP1 | |
| SCHEMBL435582 | 0.77 | POLB (0.34) | KEAP1NFE2L2KMT2A | |
| SCHEMBL1647704 | 0.68 | MAPT (0.38) | TSHRHSD17B10NPC1RAB9ATDP1 | |
| SCHEMBL14937595 | 0.68 | MAPT (0.36) | TSHRHSD17B10NPC1RAB9ATDP1 | |
| SCHEMBL436086 | 0.66 | TARBP2 (0.35) | TSHRHSD17B10TDP1KMT2A | |
| SCHEMBL436087 | 0.65 | MYC (0.37) | TSHRNPC1RAB9ATDP1HSD11B1 | |
| SCHEMBL436545 | 0.65 | MAPT (0.41) | NPC1RAB9ATDP1KEAP1NFE2L2 | |
| SCHEMBL1649411 | 0.65 | KMT2A (0.43) | TSHRHSD17B10NPC1RAB9AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | claimed |