Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HNF4A | P41235 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434903 | 0.77 | TSHR (0.32) | NPC1RAB9ATDP1TSHRHSD17B10 | |
| SCHEMBL434072 | 0.69 | TSHR (0.32) | TSHRHSD17B10KMT2AHSD11B1 | |
| SCHEMBL18294829 | 0.69 | TSHR (0.32) | TSHRHSD17B10KMT2AHSD11B1 | |
| SCHEMBL436087 | 0.65 | MYC (0.37) | NPC1RAB9ATDP1MYCMAPT | |
| SCHEMBL435582 | 0.65 | POLB (0.34) | LMNAMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27891257 | 0.64 | SMN1; SMN2 (0.50) | ALDH1A1L3MBTL1MAPTTSHRHSD17B10 | |
| SCHEMBL17480045 | 0.62 | PSIP1 (0.47) | LMNATSHRHSD17B10SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL1648768 | 0.61 | NAT1 (0.39) | NPC1RAB9ATDP1ALDH1A1L3MBTL1 | |
| SCHEMBL4912518 | 0.59 | ALDH1A1 (0.53) | TDP1ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL18393406 | 0.59 | BRD4 (0.51) | ALDH1A1MYCL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | claimed |