Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | EGFR | P00533 | 9/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.76 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | PRNP | P04156 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6186081 | 0.99 | MAPK1 (0.97) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL5564456 | 0.90 | MAPK1 (0.82) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL8871863 | 0.90 | EGFR (0.82) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL159209 | 0.86 | EGFR (1.00) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL29350058 | 0.86 | EGFR (1.00) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL11087835 | 0.85 | EGFR (0.80) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL9215676 | 0.85 | EGFR (0.74) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL8872089 | 0.85 | EGFR (1.00) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL8427296 | 0.85 | EGFR (0.74) | MAPK1EGFRERBB2HTTKDM4E | |
| SCHEMBL6188219 | 0.84 | MAPK1 (0.73) | MAPK1EGFRERBB2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | claimed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0520722-B1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LTD (GB) | 1996-12-27 | — | — | EP | disclosed |
| EP-0520722-A1 | Therapeutic preparations containing quinazoline derivatives | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |