Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.63 |
| ▸ | CD38 | P28907 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8427224 | 0.99 | EGFR (0.72) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL13620922 | 0.90 | EGFR (0.67) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL5565226 | 0.89 | HTT (0.72) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8871863 | 0.89 | EGFR (0.82) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL159209 | 0.85 | EGFR (1.00) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL29350058 | 0.85 | EGFR (1.00) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL4349199 | 0.85 | MAPK1 (1.00) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL9017048 | 0.84 | EGFR (0.70) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL8872089 | 0.84 | EGFR (1.00) | EGFRERBB2MAPK1HTTHIF1A | |
| SCHEMBL9215676 | 0.84 | EGFR (0.74) | EGFRERBB2MAPK1HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955464-A | USE OF THE RECEPTOR TYROSINE KINASE INHIBITORY PROPERTIES OF THE COMPOUNDS IN THE TREATMENT OF PROLIFERATIVE DISEASE SUCH AS CANCER | ZENECA LIMITED (GB) | 1999-09-21 | — | — | US | disclosed |
| EP-0794953-B1 | QUINAZOLINE DERIVATIVES | ZENECA LTD (GB) | 1999-05-06 | — | — | EP | disclosed |
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |