Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350717 | 1.00 | AURKA (0.46) | AURKAAURKBKMT2AAXLHDAC1 | |
| SCHEMBL4348496 | 0.87 | KMT2A (0.41) | KMT2AAXLHDAC1HDAC6MTNR1A | |
| SCHEMBL4348487 | 0.87 | KMT2A (0.41) | KMT2AAXLHDAC1HDAC6MTNR1A | |
| SCHEMBL4350005 | 0.86 | GSK3B (0.47) | KMT2AHDAC1HDAC6TP53DRD2 | |
| SCHEMBL4355310 | 0.86 | GSK3B (0.47) | KMT2AHDAC1HDAC6TP53DRD2 | |
| SCHEMBL4349997 | 0.86 | GSK3B (0.47) | KMT2AHDAC1HDAC6TP53DRD2 | |
| SCHEMBL4355315 | 0.86 | GSK3B (0.47) | KMT2AHDAC1HDAC6TP53DRD2 | |
| SCHEMBL4351416 | 0.85 | OPRL1 (0.44) | KMT2AAXLHDAC1HDAC6CDC7 | |
| SCHEMBL4353056 | 0.85 | KDM4E (0.40) | KMT2AHDAC1HDAC6TP53DRD4 | |
| SCHEMBL4351409 | 0.85 | OPRL1 (0.44) | KMT2AAXLHDAC1HDAC6CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |