Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355315 | 1.00 | GSK3B (0.47) | GSK3BKMT2AADORA2AMAPTNPSR1 | |
| SCHEMBL4350005 | 1.00 | GSK3B (0.47) | GSK3BKMT2AADORA2AMAPTNPSR1 | |
| SCHEMBL4355310 | 1.00 | GSK3B (0.47) | GSK3BKMT2AADORA2AMAPTNPSR1 | |
| SCHEMBL4352493 | 0.92 | GSK3B (0.45) | GSK3BKMT2AADORA2ADRD4HTR1A | |
| SCHEMBL4352488 | 0.92 | GSK3B (0.45) | GSK3BKMT2AADORA2ADRD4HTR1A | |
| SCHEMBL4353050 | 0.88 | KDM4E (0.40) | GSK3BKMT2AMAPTNPSR1TP53 | |
| SCHEMBL4353056 | 0.88 | KDM4E (0.40) | GSK3BKMT2AMAPTNPSR1TP53 | |
| SCHEMBL4350722 | 0.86 | AURKA (0.46) | GSK3BKMT2ATP53DRD2DRD4 | |
| SCHEMBL4350717 | 0.86 | AURKA (0.46) | GSK3BKMT2ATP53DRD2DRD4 | |
| SCHEMBL4351445 | 0.86 | GSK3B (0.62) | GSK3BKMT2AADORA2AMETHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |