Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 18/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348906 | 0.86 | EPHX2 (0.73) | EPHX2MAPTNPSR1 | |
| SCHEMBL4350003 | 0.81 | MAPT (0.49) | EPHX2MAPTNPSR1 | |
| SCHEMBL4346744 | 0.75 | EPHX2 (1.00) | EPHX2MAPT | |
| SCHEMBL4357508 | 0.74 | RAB9A (0.57) | EPHX2 | |
| SCHEMBL4341765 | 0.74 | KMT2A (0.54) | EPHX2MAPTNPSR1 | |
| SCHEMBL4359277 | 0.74 | HTT (0.51) | EPHX2 | |
| SCHEMBL4348023 | 0.74 | MEN1 (0.55) | EPHX2MAPT | |
| SCHEMBL4351202 | 0.73 | EPHX2 (0.65) | EPHX2 | |
| SCHEMBL4358407 | 0.73 | EPHX2 (0.65) | EPHX2MAPT | |
| SCHEMBL28784046 | 0.73 | GAA (0.42) | EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-1539683-A2 | PHENOL DERIVATIVES AND THEIR USE AS ROTAMASE INHIBITORS | Jerini AG (DE) | 2005-06-15 | — | — | EP | claimed |
| WO-2004026815-A2 | PHENOL DERIVATIVES AND THEIR USE AS ROTAMASE INHIBITORS | JERINI AG (DE) | 2004-04-01 | — | — | WO | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |