Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 14/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342450 | 0.88 | KDM4E (0.48) | KDM4EHSP90AA1HSP90AB1HPGDDHFR | |
| SCHEMBL4356080 | 0.84 | HPGD (0.41) | HPGDALDH1A1MAPT | |
| SCHEMBL4354045 | 0.79 | KMT2A (0.44) | HPGDALDH1A1MAPT | |
| SCHEMBL4346476 | 0.78 | HPGD (0.61) | HPGDHDAC3HDAC2ALDH1A1MAPT | |
| SCHEMBL4347126 | 0.77 | TDP1 (0.53) | KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL4347243 | 0.74 | MAPT (0.42) | KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL4349456 | 0.71 | HPGD (0.40) | HPGDALDH1A1MAPT | |
| SCHEMBL4353500 | 0.67 | ATM (0.44) | HPGDALDH1A1MAPT | |
| SCHEMBL4347278 | 0.65 | HPGD (0.59) | HPGDALDH1A1MAPT | |
| SCHEMBL15223894 | 0.65 | PTGS1 (0.46) | KDM4EHSP90AA1HSP90AB1HPGDHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088149-A1 | PHARMACOLOGICALLY ACTIVE N,N'-SUBSTITUTED 3,7-DIAZABICYCLO Ý3.3.1¨NONANES, PHARMACEUTICAL COMPOSITIONS BASED THEREON AND A METHOD FOR THE USE THEREOF | Institute of Physiologically active compunds of the Russian Academy of Sciences (IPAC RAN) (RU) | 2009-08-12 | — | — | EP | claimed |
| EP-2088149-A1 | PHARMACOLOGICALLY ACTIVE N,N'-SUBSTITUTED 3,7-DIAZABICYCLO Ý3.3.1¨NONANES, PHARMACEUTICAL COMPOSITIONS BASED THEREON AND A METHOD FOR THE USE THEREOF | Institute of Physiologically active compunds of the Russian Academy of Sciences (IPAC RAN) (RU) | 2009-08-12 | — | — | EP | disclosed |