Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 9/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353164 | 1.00 | CDC7 (0.51) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL4343116 | 0.88 | GSK3B (0.55) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL4343113 | 0.88 | GSK3B (0.55) | CDC7CDK2CCNE1DBF4GSK3B | |
| SCHEMBL4355610 | 0.87 | PDPK1 (0.50) | GSK3BKMT2AHDAC1HDAC6 | |
| SCHEMBL4344099 | 0.87 | NPSR1 (0.51) | GSK3BKMT2ARPS6KB1HDAC1ADORA2A | |
| SCHEMBL4344092 | 0.87 | NPSR1 (0.51) | GSK3BKMT2ARPS6KB1HDAC1ADORA2A | |
| SCHEMBL4355602 | 0.87 | PDPK1 (0.50) | GSK3BKMT2AHDAC1HDAC6 | |
| SCHEMBL24758014 | 0.87 | SNCA (0.51) | GSK3BMAP3K7TAB1CLK1DYRK1A | |
| SCHEMBL4346212 | 0.87 | GSK3B (0.58) | GSK3BKMT2AHDAC1ADORA2AHDAC6 | |
| SCHEMBL4346216 | 0.87 | GSK3B (0.58) | GSK3BKMT2AHDAC1ADORA2AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |