Sugi Predict

Sugi Predict / Compounds / SCHEMBL435353

SCHEMBL435353

SCHEMBL435353

O=Cc1ccc(OCc2ccccc2)cc1O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.67
▸ MAPT P10636 1/20 0.67
▸ MAOB P27338 8/20 0.58
▸ MAOA P21397 2/20 0.58
▸ LMNA P02545 1/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ PTGS1 P23219 1/20 0.56
▸ SLC6A2 P23975 1/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ PTGS2 P35354 1/20 0.56
▸ SLC6A3 Q01959 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ HDAC6 Q9UBN7 1/20 0.56
▸ TRIM24 O15164 1/20 0.56
▸ TYR P14679 1/20 0.56
▸ TRIM33 Q9UPN9 1/20 0.56
▸ ERN1 O75460 1/20 0.53
▸ ALOX5 P09917 1/20 0.53
▸ MCL1 Q07820 1/20 0.50
▸ NR4A1 P22736 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29901179 0.89 MAOB (0.56) POLBMAPTMAOBMAOALMNA
SCHEMBL3621341 0.89 MAOB (0.56) POLBMAPTMAOBMAOALMNA
SCHEMBL8327914 0.87 MAOA (0.61) POLBMAPTMAOBMAOALMNA
SCHEMBL29958502 0.85 NR4A2 (0.56) POLBMAPTTRIM24TYRTRIM33
SCHEMBL1923438 0.84 MAOB (0.59) POLBMAPTMAOBMAOATRIM24
SCHEMBL26036584 0.84 APP (0.58) POLBMAPTMAOBMAOATRIM24
SCHEMBL31166996 0.84 TRIM24 (0.71) POLBMAPTMAOBTRIM24TYR
SCHEMBL865350 0.84 MAOA (0.58) POLBMAPTMAOBMAOAERN1
SCHEMBL12917532 0.84 MAOB (0.57) POLBMAPTMAOBMAOALMNA
SCHEMBL16507010 0.83 CYP1A2 (0.55) POLBMAPTMAOBMAOALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 404 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101985449-B Coumarin derivative, and preparation method and use thereof as anti-cancer medicament UNIV SUN YAT SEN 2012-08-22 — — CN claimed
CN-102408417-A 2-substituted vinylsulfonate compound and preparation method and use thereof UNIV SHANGHAI JIAOTONG 2012-04-11 — — CN claimed
CN-102391260-A 3-ketone-6-substituted-benzofuran compound and preparation method and application thereof UNIV SHANGHAI JIAOTONG 2012-03-28 — — CN claimed
CN-102351852-A Benzofuran compound and preparation method and application thereof UNIV SHANGHAI JIAOTONG 2012-02-15 — — CN claimed
CN-101985449-A Coumarin derivative, and preparation method and use thereof as anti-cancer medicament UNIV SUN YAT SEN 2011-03-16 — — CN claimed
US-7875736-B2 catalytic metathesis ring closing; 1,4-benzyloxy-2-hydroxybenzaldehyde reacts with mixture of methyl triphenyl phosphonium bromide and potassium tert-butoxide, followed by reaction with 2-bromo-4'-methoxyacetophenone KAOHSIUNG MEDICAL UNIVERSITY (TW) 2011-01-25 — — US claimed
US-20100298582-A1 Intermediate Compounds and Processes for the Preparation of 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-25 — — US claimed
CN-122080106-A Oleanolic acid acylhydrazone derivative and preparation method and application thereof — 2026-05-26 — — CN disclosed
US-20250289789-A1 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. 2025-09-18 — — US disclosed
WO-2025090658-A2 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-05-01 — — WO disclosed
US-20240417419-A1 C-TERMINAL HSP90 INHIBITORS UNIV KANSAS (US) 2024-12-19 — — US disclosed
EP-4436956-A1 LIGANDS SPECIFICALLY TARGETING VESICULAR GLUTAMATE TRANSPORTERS FOR SUPER-RESOLUTION IMAGING Sorbonne Université (FR) 2024-10-02 — — EP disclosed
EP-4403552-A2 C-TERMINAL HSP90-INHIBITORS The University of Kansas (US) 2024-07-24 — — EP disclosed
US-4873259-A Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds ABBOTT LABORATORIES (US) 1989-10-10 — — US disclosed
US-4788214-A ANTIALLERGENS HOFFMAN-LA ROCHE INC. (US) 1988-11-29 — — US disclosed
US-4785017-A ANTIALLERGENS HOFFMANN-LA ROCHE INC. (US) 1988-11-15 — — US disclosed
EP-0279263-A2 Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds ABBOTT LABORATORIES (US) 1988-08-24 — — EP disclosed
EP-0129906-B1 PHENOXYALKOXY-3,4-DIHYDRO-2H-1-BENZOPYRAN DERIVATIVES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1988-06-08 — — EP disclosed
EP-0129906-A1 Phenoxyalkoxy-3,4-dihydro-2H-1-benzopyran derivatives F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1985-01-02 — — EP disclosed
US-3966755-A OPTICAL BRIGHTENERS CIBA-GEIGY CORPORATION (US) 1976-06-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298582-A1 Intermediate Compounds and Processes for the Preparation of 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran CYP11B1, CYP2E1, CYP1B1 POLB 707/4885MAPT 4570/4885MAOB 80/4885
US-20250289789-A1 REVERSIBLE LYSINE COVALENT MODIFIERS OF CDK2 AND USES THEREOF CDK2, CDK20, CDK1 POLB 276/4885MAPT 3329/4885MAOB 1305/4885
US-20240417419-A1 C-TERMINAL HSP90 INHIBITORS HSP90AB2P, HSP90AB1, HSP90B1 POLB 1258/4885MAPT 252/4885MAOB 4134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.