Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168758 | 0.87 | — | — | |
| SCHEMBL1900319 | 0.87 | — | — | |
| SCHEMBL23613 | 0.87 | — | — | |
| SCHEMBL669050 | 0.87 | — | — | |
| SCHEMBL27744522 | 0.84 | — | — | |
| Ammonia Solution, Strong SCHEMBL28904849 | 0.83 | — | — | |
| SCHEMBL27496697 | 0.83 | — | — | |
| Water SCHEMBL28122586 | 0.83 | — | — | |
| Carbon Dioxide SCHEMBL27523988 | 0.81 | — | — | |
| SCHEMBL29004104 | 0.80 | ALDH1A1 (0.33) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279548-B1 | Substituted 1,3,4,9-tetrahydropyrano [3,4-b] indole-1-acetic acids | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-08-19 | — | — | EP | claimed |
| US-8574771-B2 | Rechargeable lithium battery | SAMSUNG SDI CO., LTD. (KR) | 2013-11-05 | — | — | US | disclosed |
| US-7494746-B2 | Electrolyte for rechargeable lithium battery, and rechargeable lithium battery including same | SAMSUNG SDI CO., LTD. (KR) | 2009-02-24 | — | — | US | disclosed |
| US-20080118843-A1 | Electrolyte for rechargeable lithium battery, and rechargeable lithium battery including same | SAMSUNG SDI CO., LTD., A CORPORATION ORGANIZED UNDER THE LAWS OF THE REPUBLIC OF KOREA (KR) | 2008-05-22 | — | — | US | disclosed |
| US-20070154810-A1 | Rechargeable lithium battery | SAMSUNG SDI CO., LTD. (KR) | 2007-07-05 | — | — | US | disclosed |