Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 3/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785353 | 0.86 | BPTF (0.58) | BPTFPDE10AKMT2AMEN1GAA | |
| SCHEMBL4354248 | 0.81 | CYP1A2 (0.54) | PDE10ACNR2NPC1RAB9AMAPT | |
| SCHEMBL24485756 | 0.74 | CNR2 (0.46) | CNR2TP53KMT2AMEN1HTT | |
| SCHEMBL30908549 | 0.73 | CNR2 (0.59) | PDE10ACNR2MAPTKMT2AMEN1 | |
| SCHEMBL6786160 | 0.72 | BPTF (0.44) | BPTFPDE10ANPC1RAB9AMAPT | |
| SCHEMBL6789292 | 0.71 | SMN1; SMN2 (0.48) | BPTFPDE10ANPC1RAB9AMAPT | |
| SCHEMBL18255876 | 0.71 | CNR2 (0.54) | PDE10ACNR2KMT2AMEN1HTT | |
| SCHEMBL26910162 | 0.71 | BPTF (1.00) | BPTF | |
| SCHEMBL8834288 | 0.71 | MAPT (0.51) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL27409311 | 0.71 | CNR2 (0.56) | PDE10ACNR2KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026241-A1 | HETEROCYCLIC MODULATORS OF TGR5 | KALYPSYS, INC. (US) | 2009-02-26 | — | — | WO | disclosed |