Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 5/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786160 | 0.87 | BPTF (0.44) | BPTFPDE10AKMT2ASMN1; SMN2BRD4 | |
| SCHEMBL4354244 | 0.86 | BPTF (0.56) | BPTFPDE10AKMT2ASMN1; SMN2GAA | |
| SCHEMBL6789292 | 0.85 | SMN1; SMN2 (0.48) | BPTFPDE10AKMT2ASMN1; SMN2BRD4 | |
| SCHEMBL6784797 | 0.83 | PDE10A (0.56) | BPTFPDE10ASMN1; SMN2BRD4KAT2B | |
| SCHEMBL6786035 | 0.81 | FLT1 (0.56) | BPTFPDE10ABRD4KAT2BBRD9 | |
| SCHEMBL6784809 | 0.78 | CXCL8 (0.46) | BPTFSMN1; SMN2BRD4KAT2BBRD9 | |
| SCHEMBL1777658 | 0.74 | LPAR1 (0.42) | KMT2ASMN1; SMN2GAAKDM4EMEN1 | |
| SCHEMBL26910162 | 0.73 | BPTF (1.00) | BPTFBRD4KAT2BBRD9 | |
| SCHEMBL6787123 | 0.73 | BPTF (0.50) | BPTFPDE10ASMN1; SMN2BRD4KAT2B | |
| SCHEMBL6786512 | 0.71 | BPTF (0.48) | BPTFSMN1; SMN2BRD4KAT2BBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686373-B2 | ANALGESICS; ANTIINFLAMMATORY AGENT | WARNER-LAMBERT COMPANY LLC | 2004-02-03 | — | — | US | disclosed |
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | KAWAMURA KIYOSHI (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1310498-A2 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PFIZER INC. (US) | 2003-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PRKCB, PRKCA, PRKCG | BPTF 4059/4885PDE10A 2059/4885KMT2A 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.