SCHEMBL4354683

SCHEMBL4354683

C#Cc1cccc(Nc2ncnc3ccc(OC)cc23)c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 16/20 0.73
MAPT P10636 2/20 0.73
FBP1 P09467 2/20 0.73
GAK O14976 2/20 0.73
ALDH1A1 P00352 1/20 0.73
GRM1 Q13255 1/20 0.65
HDAC3 O15379 1/20 0.64
HDAC4 P56524 1/20 0.64
HDAC1 Q13547 1/20 0.64
HDAC7 Q8WUI4 1/20 0.64
HDAC2 Q92769 1/20 0.64
HDAC10 Q969S8 1/20 0.64
HDAC11 Q96DB2 1/20 0.64
HDAC8 Q9BY41 1/20 0.64
HDAC6 Q9UBN7 1/20 0.64
HDAC9 Q9UKV0 1/20 0.64
HDAC5 Q9UQL6 1/20 0.64
ERBB2 P04626 5/20 0.64
PDGFRA P16234 2/20 0.64
LTK P29376 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1507575 0.99 EGFR (0.72) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL15051921 0.91 BRAF (0.72) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL31167366 0.91 EGFR (0.73) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL31167368 0.91 EGFR (0.73) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL1507676 0.91 EGFR (0.73) EGFRMAPTFBP1GAKALDH1A1
Hydrochloric Acid SCHEMBL1507772 0.90 EGFR (0.72) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL1507747 0.86 EGFR (0.62) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL642238 0.86 EGFR (0.71) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL1507649 0.85 EGFR (0.64) EGFRMAPTFBP1GAKALDH1A1
SCHEMBL667895 0.85 EGFR (1.00) EGFRMAPTFBP1GAKALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070328-A1 MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-06-04 WO disclosed