Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574454 | 0.84 | PDE4D (0.46) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3849702 | 0.83 | PDE4D (0.64) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL14006504 | 0.81 | ADORA1 (0.44) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3853102 | 0.80 | POLB (0.56) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3846991 | 0.77 | PDE4D (0.47) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3855819 | 0.77 | PDE4D (0.47) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL21585140 | 0.76 | PDE4D (0.50) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3848316 | 0.75 | KDM4E (0.52) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL20338259 | 0.74 | PDE4D (0.66) | PDE4DADORA1PDE1APDE1BPDE3B | |
| SCHEMBL3847496 | 0.72 | HPGDS (0.60) | ALDH1A1SMN1; SMN2LMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |