Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.57 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.57 |
| ▸ | TYMS | P04818 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 8/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55254 | 0.97 | — | — | |
| SCHEMBL27627928 | 0.93 | LPAR3 (0.57) | LPAR3LPAR2TYMSFDPSALDH1A1 | |
| SCHEMBL21384981 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL2150592 | 0.93 | — | — | |
| SCHEMBL28679157 | 0.93 | — | — | |
| Ammonia Solution, Strong SCHEMBL9814422 | 0.93 | — | — | |
| SCHEMBL6361208 | 0.93 | — | — | |
| SCHEMBL6364192 | 0.93 | — | — | |
| SCHEMBL28547737 | 0.93 | — | — | |
| SCHEMBL11402379 | 0.90 | LPAR3 (0.55) | LPAR3LPAR2TYMSFDPSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404873-A4 | CHIMERIC IMMUNOMODULATORY COMPOUNDS AND METHODS OF USING THE SAME | DYNAVAX TECH CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1404873-A2 | CHIMERIC IMMUNOMODULATORY COMPOUNDS AND METHODS OF USING THE SAME | Dynavax Technologies Corporation (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000922-A2 | CHIMERIC IMMUNOMODULATORY COMPOUNDS AND METHODS OF USING THE SAME | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |