Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.57 |
| ▸ | MDM4 | O15151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | TLR2 | O60603 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4359904 | 0.97 | MDM2 (0.56) | MDM2MDM4TP53TLR2KMT2A | |
| SCHEMBL21315799 | 0.94 | MDM2 (0.57) | MDM2MDM4TP53TLR2KMT2A | |
| SCHEMBL13946896 | 0.94 | MDM2 (0.57) | MDM2MDM4TP53TLR2KMT2A | |
| SCHEMBL29460051 | 0.94 | MDM2 (0.57) | MDM2MDM4TP53TLR2KMT2A | |
| SCHEMBL31317450 | 0.94 | MDM2 (0.57) | MDM2MDM4TP53TLR2KMT2A | |
| SCHEMBL5053659 | 0.94 | MDM2 (0.57) | MDM2MDM4TP53TLR2KMT2A | |
| Trifluoroacetic Acid SCHEMBL4363443 | 0.94 | MDM2 (0.54) | MDM2MDM4TP53TLR2KMT2A | |
| Hydrochloric Acid SCHEMBL25357604 | 0.93 | MDM2 (0.56) | MDM2MDM4TP53TLR2KMT2A | |
| Hydrochloric Acid SCHEMBL29399028 | 0.93 | MDM2 (0.56) | MDM2MDM4TP53TLR2KMT2A | |
| Hydrochloric Acid SCHEMBL28469862 | 0.93 | MDM2 (0.56) | MDM2MDM4TP53TLR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1923397-B1 | Fluorinated amino acids and peptides | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-10-28 | — | — | EP | disclosed |
| EP-1923397-A1 | Fluorinated amino acids and peptides | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-05-21 | — | — | EP | disclosed |
| EP-1921062-A2 | Amino acid derivatives as HIV aspartyl protease inhibitors | Ambrilia Biopharma Inc. (CA) | 2008-05-14 | — | — | EP | disclosed |
| EP-1458378-B1 | AMINO ACID DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | disclosed |
| US-20060079550-A1 | Amino acid derivatives useful for the treatment of alzheimer's disease | ELAN PHARMACEUTICALS, INC. | 2006-04-13 | — | — | US | disclosed |
| EP-1263716-A2 | AMINO ACID DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | Pharmacor Inc. (CA) | 2002-12-11 | — | — | EP | disclosed |
| US-6455587-B1 | AROMATIC SULFONYL DERIVATIVES | PHARMACOR INC. (CA) | 2002-09-24 | — | — | US | disclosed |
| WO-2001068593-A2 | AMINO ACID DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | PHARMACOR INC. (CA) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079550-A1 | Amino acid derivatives useful for the treatment of alzheimer's disease | BACE1, APP, PSEN1 | MDM2 1094/4885MDM4 2897/4885TP53 2104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.