Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.38 |
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.37 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361545 | 0.93 | EGLN3 (0.46) | EGLN3HDAC3HDAC2HDAC8EZH2 | |
| SCHEMBL3847256 | 0.87 | HDAC8 (0.42) | EGLN3HDAC3HDAC2HDAC8EZH2 | |
| SCHEMBL4363479 | 0.83 | NMT1 (0.40) | EGLN3 | |
| SCHEMBL3849099 | 0.79 | EGLN3 (0.47) | EGLN3HDAC3HDAC2HDAC8EZH2 | |
| SCHEMBL4361363 | 0.78 | PTGDR2 (0.48) | EGLN3EGLN1HIF1A | |
| SCHEMBL4359883 | 0.77 | EGLN3 (0.45) | EGLN3HDAC3HDAC2AOC3EGLN1 | |
| SCHEMBL4371854 | 0.74 | EGLN3 (0.54) | EGLN3EGLN1HIF1A | |
| SCHEMBL4365040 | 0.73 | EGLN3 (0.48) | EGLN3EGLN1HIF1A | |
| SCHEMBL4359069 | 0.73 | EGLN3 (0.51) | EGLN3HDAC3HDAC2HDAC8EGLN1 | |
| SCHEMBL4362443 | 0.73 | EGLN3 (0.52) | EGLN3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |