Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356608 | 0.96 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4360852 | 0.94 | ALK (0.45) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4361963 | 0.94 | ALK (0.39) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4359427 | 0.93 | ALK (0.40) | ALDH1A1NPSR1CCR6ALKUSP2 | |
| Trifluoroacetic Acid SCHEMBL4358593 | 0.91 | ALK (0.41) | ALKRORCMAPTJAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL4361583 | 0.91 | ALK (0.41) | ALKRORCJAK2JAK1TYK2 | |
| Trifluoroacetic Acid SCHEMBL4360610 | 0.90 | CCR6 (0.39) | ALDH1A1CCR6ALKGAAJAK2 | |
| Trifluoroacetic Acid SCHEMBL4363125 | 0.90 | JAK2 (0.40) | ALKGAARORCJAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL4361197 | 0.90 | ALK (0.37) | SMN1; SMN2ALDH1A1CYP3A4ALKUSP2 | |
| SCHEMBL13622667 | 0.89 | ALK (0.49) | SMN1; SMN2POLBALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | SMN1; SMN2 4274/4885POLB 2346/4885ALDH1A1 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.