Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.39 |
| ▸ | CDK14 | O94921 | 8/20 | 0.36 |
| ▸ | CCNY | Q8ND76 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363845 | 0.96 | ALK (0.42) | ALKALDH1A1POLBCYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4361782 | 0.95 | ALK (0.45) | ALKCDK14CCNYALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL4356274 | 0.94 | SMN1; SMN2 (0.43) | ALKALDH1A1POLBCYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4359427 | 0.92 | ALK (0.40) | ALKCDK14CCNYALDH1A1NPSR1 | |
| SCHEMBL13622663 | 0.91 | ALK (0.48) | ALKALDH1A1POLBCYP3A4CYP2D6 | |
| SCHEMBL13634059 | 0.90 | ALK (0.36) | ALKALDH1A1POLBSMN1; SMN2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL4360852 | 0.90 | ALK (0.45) | ALKALDH1A1POLBCYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4361804 | 0.90 | HTT (0.40) | ALKCDK14CCNYALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL4358794 | 0.90 | ALK (0.39) | ALKCDK14CCNYPOLBL3MBTL1 | |
| SCHEMBL4356608 | 0.89 | SMN1; SMN2 (0.41) | ALKALDH1A1POLBCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | ALK 3/4885CDK14 374/4885CCNY 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.