Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774900 | 0.82 | TLR8 (0.36) | TLR8MAOALIPGMAOBCETP | |
| SCHEMBL3780924 | 0.80 | TLR8 (0.35) | TLR8MAOALIPGMAOBCETP | |
| SCHEMBL5575415 | 0.80 | TLR8 (0.36) | TLR8MAOALIPGMAOBCETP | |
| SCHEMBL4352007 | 0.76 | TLR8 (0.38) | TLR8MAOALIPGMAOBCETP | |
| SCHEMBL3780304 | 0.76 | ESR1 (0.37) | TLR8MAOALIPGMAOBCETP | |
| SCHEMBL14378804 | 0.72 | TYR (0.38) | TLR8MAOALIPGMAPTMEN1 | |
| SCHEMBL11227235 | 0.71 | TLR8 (0.59) | TLR8LIPGMAPTMEN1TP53 | |
| SCHEMBL11229645 | 0.71 | TLR8 (0.59) | TLR8LIPGMAPTMEN1TP53 | |
| SCHEMBL27904719 | 0.70 | MAPT (0.39) | TLR8LIPGMAPTMEN1TP53 | |
| SCHEMBL11958250 | 0.70 | TYR (0.36) | TLR8MAOALIPGMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105042-A1 | THIENOTHIOPHENE DERIVATIVES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2009-08-27 | — | — | WO | disclosed |