Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361046 | 0.78 | PROKR1 (0.43) | — | |
| SCHEMBL4327043 | 0.77 | HRH4 (0.63) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL3540795 | 0.74 | POLB (0.51) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL2347853 | 0.73 | POLB (0.63) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL24235367 | 0.71 | AKR1C3 (0.61) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL30310614 | 0.70 | AKR1C3 (0.60) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL13753537 | 0.69 | AKR1C3 (0.62) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL15064997 | 0.69 | AKR1C3 (0.62) | POLBSMN1; SMN2AKR1C3HRH4HRH3 | |
| SCHEMBL28551515 | 0.69 | KDM4E (0.44) | POLBSMN1; SMN2AKR1C3HRH4 | |
| SCHEMBL25040621 | 0.69 | HRH4 (0.64) | AKR1C3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |