Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 10/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356795 | 0.78 | POLB (0.50) | — | |
| SCHEMBL3542599 | 0.76 | KMT2A (0.48) | PROKR1 | |
| SCHEMBL3540193 | 0.70 | PROKR1 (0.45) | PROKR1 | |
| SCHEMBL4366003 | 0.68 | HRH3 (0.53) | — | |
| SCHEMBL3539000 | 0.68 | HRH3 (0.54) | PROKR1 | |
| SCHEMBL27739826 | 0.68 | HRH3 (0.40) | PROKR1 | |
| SCHEMBL3540158 | 0.68 | HRH3 (0.40) | PROKR1 | |
| SCHEMBL3534607 | 0.66 | ALDH1A1 (0.41) | PROKR1 | |
| SCHEMBL4373527 | 0.66 | HRH3 (0.44) | — | |
| SCHEMBL4365923 | 0.64 | HRH3 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |