Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iloprost. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR known ✓ | P43119 | 2/20 | 1.00 |
| ▸ | PTGER3 | P43115 | 2/20 | 1.00 |
| ▸ | PTGER2 | P43116 | 2/20 | 1.00 |
| ▸ | PTGER1 | P34995 | 1/20 | 1.00 |
| ▸ | PTGDR | Q13258 | 1/20 | 1.00 |
| ▸ | PPARD | Q03181 | 2/20 | 0.64 |
| ▸ | PPARA | Q07869 | 2/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 12/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iloprost SCHEMBL9769181 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL9769188 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL9718500 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509111 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509108 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509107 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509137 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509174 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL20687610 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL15955636 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15412 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144751-A1 | LIPOSOME COMPOSITIONS COMPRISING WEAK ACID DRUGS AND USES THEREOF | PHARMOSA BIOPHARM INC. (TW) | 2026-05-28 | — | — | US | claimed |
| EP-4746889-A1 | METHOD OF USING ILOPROST FOR TREATING FROSTBITE | BTG International Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3810091-B1 | COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION | ABRAXIS BIOSCIENCE LLC (US) | 2026-05-20 | — | — | EP | claimed |
| US-12622949-B2 | Compositions containing rapid-acting insulin analogues | CASE WESTERN RESERVE UNIVERSITY (US) | 2026-05-12 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12616803-B2 | Apparatus for dispensing inhalant medicament | METOPI PHARMACEUTICALS, INC. (US) | 2026-05-05 | — | — | US | claimed |
| EP-3969002-B1 | PHARMACEUTICAL COMPOSITION OF A WEAK ACID DRUG AND METHODS OF ADMINISTRATION | PHARMOSA BIOPHARM INC (TW) | 2026-04-22 | — | — | EP | claimed |
| US-20260069535-A1 | NEBULIZER KITS AND USES THEREOF | PHARMOSA BIOPHARM INC (TW) | 2026-03-12 | — | — | US | claimed |
| US-12551437-B2 | Liposome compositions comprising weak acid drugs and uses thereof | PHARMOSA BIOPHARM INC. (TW) | 2026-02-17 | — | — | US | claimed |
| EP-0324745-A1 | TOPICAL AGENT CONTAINING PROSTACYCLINE DERIVATIVES. | SCHERING AG (DE) | 1989-07-26 | — | — | EP | claimed |
| EP-0268581-A1 | PROSTACYCLINES, THEIR ANALOGUES OR PROSTAGLANDINES AND THROMBOXANE ANTAGONISTS FOR THE TREATMENT OF THROMBOTIC AND THROMBO-EMBOLIC ILLNESSES. | SCHERING AG (DE) | 1988-06-01 | — | — | EP | claimed |
| EP-0261798-A2 | Fertility control | O'Neill, Christopher (AU) | 1988-03-30 | — | — | EP | claimed |
| WO-1988001867-A1 | TOPICAL AGENT CONTAINING PROSTACYCLINE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-24 | — | — | WO | claimed |
| EP-0257859-A2 | Novel combination | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-03-02 | — | — | EP | claimed |
| EP-0228988-A1 | Treatment of thrombosis with fibrinolytics and prostacyclins | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-07-15 | — | — | EP | claimed |
| WO-1987003488-A1 | TREATMENT OF THROMBOSIS WITH FIBRINOLYTIC AGENTS AND PROSTACYCLINES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-06-18 | — | — | WO | claimed |
| WO-1987000434-A1 | PROSTACYCLINES, THEIR ANALOGUES OR PROSTAGLANDINES AND THROMBOXANE ANTAGONISTS FOR THE TREATMENT OF THROMBOTIC AND THROMBO-EMBOLIC ILLNESSES | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1987-01-29 | — | — | WO | claimed |
| EP-0191792-A1 | PROSTACYCLINE DERIVATIVES WITH A CYTOPROTECTIVE ACTION ON THE KIDNEY. | SCHERING AG (DE) | 1986-08-27 | — | — | EP | claimed |
| WO-1986000808-A1 | PROSTACYCLINE DERIVATIVES WITH A CYTOPROTECTIVE ACTION ON THE LIVER, THE PANCREAS AND THE KIDNEY | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-13 | — | — | WO | claimed |