Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iloprost. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR known ✓ | P43119 | 2/20 | 1.00 |
| ▸ | PTGER3 | P43115 | 2/20 | 1.00 |
| ▸ | PTGER2 | P43116 | 2/20 | 1.00 |
| ▸ | PTGER1 | P34995 | 1/20 | 1.00 |
| ▸ | PTGDR | Q13258 | 1/20 | 1.00 |
| ▸ | PPARD | Q03181 | 2/20 | 0.64 |
| ▸ | PPARA | Q07869 | 2/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 12/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iloprost SCHEMBL17510362 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL6083382 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL13658124 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509111 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509108 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509107 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509137 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL21509174 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL20687610 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR | |
| Iloprost SCHEMBL532499 | 1.00 | PTGIR (1.00) | PTGIRPTGER3PTGER2PTGER1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286494-A | Medicinal agents with sustained action | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-15 | — | — | US | claimed |
| EP-1933881-B1 | SOLID POLYMER DELIVERY COMPOSITIONS AND METHODS FOR USE THEREOF | MEDIVAS LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-2413909-B1 | MULTIAMINO ACID-BASED POLY (ESTER AMIDE)S | UNIV CORNELL (US) | 2016-11-30 | — | — | EP | disclosed |
| US-8993686-B2 | Multiamino acid-based poly(ester amide)s | CORNELL UNIVERSITY (US) | 2015-03-31 | — | — | US | disclosed |
| US-8841440-B2 | Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof | CORNELL UNIVERSITY (US) | 2014-09-23 | — | — | US | disclosed |
| US-8652504-B2 | Solid polymer delivery compositions and methods for use thereof | MEDIVAS, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-20120123064-A1 | Multiamino Acid-Based Poly(Ester Amide)s | CORNELL UNIVERSITY (US) | 2012-05-17 | — | — | US | disclosed |
| US-8163269-B2 | Bioactive stents for type II diabetics and methods for use thereof | MEDIVAS, LLC | 2012-04-24 | — | — | US | disclosed |
| EP-2413909-A1 | MULTIAMINO ACID-BASED POLY (ESTER AMIDE)S | Cornell University (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20110150999-A1 | Organo-Soluble Chitosan Salts and Chitosan-Derived Biomaterials Prepared Thereof | CORNELL UNIVERSITY | 2011-06-23 | — | — | US | disclosed |
| EP-1603485-A2 | BIOACTIVE STENTS AND METHODS FOR USE THEREOF | Medivas, LLC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20050238689-A1 | Bioactive stents for type II diabetics and methods for use thereof | MEDIVAS, LLC (US) | 2005-10-27 | — | — | US | disclosed |
| WO-2005097186-A2 | BIOACTIVE STENTS FOR TYPE II DIABETICS AND METHODS FOR USE THEREOF | MEDIVAS, LLC (US) | 2005-10-20 | — | — | WO | disclosed |
| WO-2004075781-A2 | BIOACTIVE STENTS AND METHODS FOR USE THEREOF | MEDIVAS, LLC (US) | 2004-09-10 | — | — | WO | disclosed |
| US-20040170685-A1 | Bioactive stents and methods for use thereof | MEDIVAS, LLC (US) | 2004-09-02 | — | — | US | disclosed |
| EP-1313794-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018477-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2002-03-07 | — | — | WO | disclosed |
| US-5593687-A | Aqueous dispersion containing liposomes | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5286494-A | Medicinal agents with sustained action | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-15 | — | — | US | disclosed |
| US-5110475-A | PROCESS FOR THE PREPARATION OF AQUEOUS DISPERSIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050238689-A1 | Bioactive stents for type II diabetics and methods for use thereof | CD47, ITGB2, ITGA2 | PTGIR 238/4885PTGER3 462/4885PTGER2 179/4885 |
| US-20110150999-A1 | Organo-Soluble Chitosan Salts and Chitosan-Derived Biomaterials Prepared Thereof | CHIA, CHI3L2, CHI3L1 | PTGIR 1598/4885PTGER3 3910/4885PTGER2 4415/4885 |
| US-20040170685-A1 | Bioactive stents and methods for use thereof | TGFB1, TGFB2, FGF2 | PTGIR 76/4885PTGER3 1540/4885PTGER2 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.