Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29483480 | 1.00 | HDAC1 (0.63) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL12679023 | 0.93 | HDAC1 (0.69) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL28567500 | 0.90 | DRD4 (0.61) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL12679041 | 0.89 | HDAC1 (0.64) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL29483474 | 0.88 | HDAC1 (0.63) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL1461825 | 0.88 | HDAC1 (0.63) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL11784819 | 0.86 | HDAC1 (0.61) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL29483477 | 0.86 | HDAC1 (0.61) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL29483472 | 0.86 | HDAC1 (0.65) | HDAC1HDAC6HDAC3HDAC2GAA | |
| SCHEMBL1772155 | 0.86 | HDAC1 (0.65) | HDAC1HDAC6HDAC3HDAC2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812060-B | Arylation method of tetrahydroquinoline | 绍兴文理学院 | 2022-04-29 | — | — | CN | disclosed |
| CN-112812060-A | Arylation method of tetrahydroquinoline | 绍兴文理学院 | 2021-05-18 | — | — | CN | disclosed |
| US-8883841-B2 | Oncogenic ras-specific cytotoxic compound and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-11-11 | — | — | US | disclosed |
| EP-1956910-B1 | ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2014-09-17 | — | — | EP | disclosed |
| US-20090286847-A1 | ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-11-19 | — | — | US | disclosed |
| US-3948877-A | POLYACRYLONITRILE, ACID MODIFIED POLYESTERS OR POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286847-A1 | ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | HDAC1 1148/4885HDAC6 1132/4885HDAC3 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.