Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | DNM1L | O00429 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952859 | 0.78 | ALDH1A1 (0.54) | GPR35DNM1LCHEK1HPGDSALDH1A1 | |
| SCHEMBL4350914 | 0.78 | HDAC1 (0.51) | ARHPGDS | |
| SCHEMBL2928098 | 0.76 | HPGD (0.49) | ARALDH1A1 | |
| SCHEMBL369872 | 0.74 | CYP19A1 (0.59) | IRAK4HPGDSALDH1A1 | |
| SCHEMBL31122128 | 0.73 | CHEK1 (0.47) | GPR35DNM1LCHEK1ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL31122121 | 0.73 | CHEK1 (0.47) | GPR35DNM1LCHEK1ILKAR | |
| SCHEMBL29859845 | 0.72 | KCNH2 (0.48) | ILKAKT1AKT2ARALDH1A1 | |
| SCHEMBL2925411 | 0.71 | CYP19A1 (0.56) | ALDH1A1 | |
| SCHEMBL252583 | 0.71 | HDAC3 (0.38) | — | |
| Succinic Acid SCHEMBL31122141 | 0.71 | CHEK1 (0.43) | GPR35DNM1LCHEK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231654-B1 | NEW 2-SUBSTITUTED TIAZOL-4-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS MEDICINE | BAYER IP GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2070925-A1 | New 2-substituted tiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |