Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.60 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528572 | 0.95 | HSD11B1 (0.63) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL4538415 | 0.87 | HSD11B1 (0.75) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL5638283 | 0.86 | HSD11B1 (0.56) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL4530292 | 0.82 | HSD11B1 (0.50) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL2667471 | 0.81 | HSD11B1 (0.79) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL13902645 | 0.80 | HSD11B1 (0.49) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL5637560 | 0.76 | HSD11B1 (0.43) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL827105 | 0.74 | HSD11B1 (1.00) | HSD11B1HSD11B2NR1I2CYP2C19 | |
| SCHEMBL2667625 | 0.74 | HSD11B1 (0.78) | HSD11B1 | |
| SCHEMBL13902521 | 0.74 | HSD11B1 (0.46) | HSD11B1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532122-B1 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK SHARP & DOHME (US) | 2011-12-14 | — | — | EP | disclosed |
| EP-1532122-B1 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK SHARP & DOHME (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2009073460-A2 | INHIBITION OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 FOR OCULAR NEUROPROTECTION | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-6730690-B2 | DELAYING THE ONSET OR REDUCING THE RISK OF DEVELOPING ATHEROSCLEROSIS IN A HUMAN PATIENT COMPRISING ADMINISTERING TO SAID PATIENT AN EFFECTIVE AMOUNT OF A COMPOUND OF INVENTION AND AN HMG-COA REDUCTASE INHIBITOR | MERCK & CO., INC. | 2004-05-04 | — | — | US | disclosed |