Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22749246 | 0.80 | USP5 (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL22749247 | 0.80 | USP5 (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29508406 | 0.79 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29508402 | 0.77 | TLR7 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL22774125 | 0.77 | USP5 (0.36) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL22749243 | 0.77 | TLR7 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL22774320 | 0.73 | TLR7 (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29604384 | 0.73 | ITGB1 (0.41) | LMNATLR7TSHRGAASMN1; SMN2 | |
| SCHEMBL3675521 | 0.72 | USP5 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL27653763 | 0.72 | USP5 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485432-B2 | Selective modulation of TLR-mediated biological activity | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-02-03 | — | — | US | disclosed |
| WO-2005032484-A9 | Alkoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES CO (US) | 2006-05-18 | — | — | WO | disclosed |